Research project P3/42 (Research action P3)
OBJECTIVES.
Study, at the cellular and organ level, of fundamental genetic mechanisms determining early embryonic development and differentiation, the organisation and interaction of cells within a tissue architecture, normal and malignant cell proliferation, normal and premature senescence, the pathogenesis of genetic diseases and anomalies, malignancy, gene mapping.
THEME.
Division of the fertilized egg (mono- and dizygotic twins); molecular mechanisms of cell adhesion and de-adhesion of normal, genetically abnormal and cancer cells; structure, function and regulation of genes; protease inhibitors; various types of heparan sulphate proteoglycans; chromosomal and molecular aberrations in leukaemia and cancer; study of gene defects in a series of diseases as well as in mental handicaps; image analysis of human chromosomes.
