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Neuro-endocrine interactions in the gastro-intestinal tract under normal and pathological conditions

Research project P5/20 (Research action P5)


Persons :


Description :

The new project proposal is a perfect continuation of the project carried out within the framework of IUAP IV and thus aims at continuing the interdisciplinary research on the neuroendocrine interactions in the digestive tract under normal and pathological condictions with special focus on six main lines of investigation:

1. Morphological, pharmacological and electrophysiological analysis of enteric microcircuits in mammals including man under normal and pathological conditions (working package: enteric microcircuits)

2. Inhibitory neurotransmission in the digestive tract (working package: inhibitory neurotransmission)

3. Pathogenesis of intestinal suffering and interaction between the enteric nervous system and the immune system in schistosomiasis, TNBS-induced ileitis, chemically induced inflammation and axotomy-induced neurochemical changes and ileus (working package: inflammation)

4. Role of VPAC1, VPAC2, PAC1, glucagon and CGRP in the digestive tract (working package: VPAC-PAC)

5. Role of ghrelin/ghrelin receptors (in relation to motilin and motilides) in the digestive tract and (working package: ghrelin)

6. Role of ICCs in the control of gastrointestinal motility under normal and pathological conditions (working package: ICC).


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