Onderzoeksproject PX/8/LP/10 (Onderzoeksactie PX)
In normal adults, bone formation is in equilibrium with bone resorption. Skeletal unloading in humans and rats, as seen during spaceflight, induces a decrease in bone formation and a transient increase in bone resorption resulting in bone loss and compromised bone mechanical properties (1). Several experimental data indicate that osteoblasts function inappropriately in microgravity. Understanding the underlying mechanisms of this process will certainly contribute to the prevention and treatment of space flight induced osteopenia but also to age-related osteoporosis.
Satellite(s) or flight opportunity(ies):
- Biobox-6 on Foton-M3
- Biolab on ISS
Field of research:
- Biology: Cell & Developmental Biology
- Human Physiology: Bone & Muscle Research