| Source DB | nl |
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| Institution | KU Leuven |
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| Code | a2eabebf-9a20-425a-91f8-6e33d7479676 |
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| Unit | 61a9f0d7-1f47-46b1-9a91-25973d85f88e
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| Begin | 10/4/2017 |
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| End | 10/4/2021 |
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| title fr |
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| title nl | Metabole uitdagingen in psoriasis artritis
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| title en | Metabolic challenges in psoriatic arthritis
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| Description fr |
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| Description nl | Psoriasis (Pso) en psoriasis artritis (PsA) zijn geassocieerd met meerdere comorbiditeiten zoals type 2 diabetes, arteriële hypertensie, metabole syndroom en coronaire hartziekte. Metabole veranderingen, geinduceerd door de chronische inflammatoir proces bijdragen aan de comorbiditeiten en het laatste kunnen de prognose en de outcome van de primair ziekte beïnvloeden. In dit werk willen we: - Aanwezigheid van de comorbiditeiten in patiënten met Pso en PsA te documenteren en stoornissen in de verschillende metabole pathways te beoordelen; - Metabole signatures van de PsA patienten en hun correlatie met de ziekteactiviteit en agressiviteit te beoordelen; - Evolutie van de baseline factoren en comorbiditeiten over een bepaalde tijd te analyseren
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| Description en | Psoriasis (and psoriatic arthritis are associated with several comorbidities such as type II diabetes, arterial hypertension, metabolic syndrome and coronary disease. Metabolic alterations induced by a chronic inflammatory process contribute directly to comorbidities and the latter may also affect the outcome and prognosis of the primary disease process. The objectives of this work are: - to determine the presence of clinical comorbidities in patients with psoriatic arthritis (PsA) and document disturbances in different metabolic pathways - to determine the metabolic signatures of PsA patients and their correlation with the severity of the disease - to identify baseline factors correlating with the severity of the disease and disease activity - to analyse evolution of the baseline factors and development of comorbidities over time
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| Qualifiers | - metabolomics - psoriasis - psoriasis artritis - |
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| Personal | Lories Rik, Ishchenko Alla |
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| Collaborations | |
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