| Source DB | nl |
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| Institution | KU Leuven |
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| Code | bfd424c1-1577-4b46-a009-f446ed5eae14 |
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| Unit | ec003d81-8401-4886-a1ef-719ecebb74b7
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| Begin | 10/29/2018 |
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| End | 10/29/2022 |
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| title fr |
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| title nl | De Hippo pathway als doelwit in kankertherapie: Onderzoek naar endogene antitumorale mechanismen
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| title en | Targeting the Hippo pathway for cancer therapy: Discovering endogenous tumor suppressor mechanisms
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| Description fr |
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| Description nl | Tumoren bestaan niet enkel uit tumor cellen maar uit vele andere, genetisch normale stromale cellen die gerekruteerd worden in groeiende tumoren. Hierbij behoren endotheelcellen die de bloedvaten opbouwen, fibroblasten die extracellulaire matrix produceren en vele types immuuncellen die zowel tumor stimulerende als inhiberende effecten kunnen hebben. Tumoren zijn dus complexe structuren waarin reciproke signaling tussen verschillende celtypes essentieel is voor hun groei en overleving. Daarom wordt er inderdaad veel onderzoek gedaan naar het ontrafelen van de complex interacties tussen tumorcellen en cellen van de tumoromgeving, in de hoop nieuwe zwakheden te vinden die gebruikt zouden kunnen worden voor kankertherapie. Dit heeft al geleid tot de ontdekking van nieuwe strategieën om kanker te behandelen zoals anti-angiogene therapie en immunotherapie. Deze strategieën richten zich op stromale cellen om tumoren te verzwakken of de kanker direct aan te vallen. Hoewel de tumoromgeving al uitgebreid werd onderzocht, begrijpen we nog niet volledig hoe tumorcellen reageren op veranderingen in andere cellulaire compartimenten van de tumor micro-omgeving. In dit project zal ik een nieuw non-cell autonoom tumor suppressor mechanisme bestuderen dat wordt aangedreven door endotheliale Yap en Taz.
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| Description en | Tumors not only comprise tumor cells but many other, genetically normal stromal cells that are recruited into growing tumors. These include endothelial cells that build new blood vessels, fibroblasts that produce extracellular matrix, and various types of immune cells that can have tumor promoting or tumor suppressing effects. Tumors are thus complex structures where reciprocal signaling between different cell types is essential for their growth and survival. Indeed, much effort is directed to deciphering the complex interdependencies between tumor cells and cells of the tumor microenvironment with the hope to identify novel vulnerabilities that could be targeted for cancer therapy. Notably, these efforts resulted in the invention of novel approaches to treat cancer, such as anti-angiogenic therapy and immunotherapy, which target stromal cells in order to weaken tumors or directly attack cancer. Although the tumor microenvironment has been vigorously studied, our understanding on how tumor cells react to changes in other cellular compartments of the tumor microenvironment remains incomplete. In this project, I will study a non-cell autonomous tumor suppressor mechanism driven by endothelial Yap and Taz.
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| Qualifiers | - Hippo pathway - YAP/TAZ - cholangiocarcinoma - hepatocellular carcinoma - mouse models for liver cancer - tumor elimination - tumorassociated vasculature - |
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| Personal | Halder Georg, Algueró Nadal Ana |
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