| Source DB | nl |
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| Institution | KU Leuven |
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| Code | dedd2922-027d-4543-9665-f5d0b4683007 |
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| Unit | 21b57562-ae7e-405a-a14c-640e8bded47d
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| Begin | 1/1/2019 |
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| End | 12/31/2022 |
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| title fr |
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| title nl | Oraal microbiële slagvelden door antiseptica: een fast-food festijn voor orale pathogenen?
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| title en | Antiseptic induced oral microbial massacres: a fast-food feast for oral pathogens?
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| Description fr |
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| Description nl | Dit project heeft tot doel het effect van deze dode bacteriën op de uitgroei en de verhoogde virulentie van pathogenen in tandplak te onderzoeken. Door gebruik te maken van verschillende modellen met toenemende complexiteit, klinische realiteit, zal een mechanistisch model zo dicht mogelijk worden gedemonstreerd. Tenslotte zal een proof of principle worden gegeven in een klinische studie.
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| Description en | Each day, most of us brush their teeth and/or rinse their mouth with oral hygiene products that contain substances that kill bacteria (antiseptics). Unfortunately, often manual plaque removal by means of a toothbrush or interdental cleaning devices is not perfect. Consequently, dental plaque, a poly-microbial biofilm is left behind. It is well known that the used antiseptics will only kill the bacteria in the upper layers of these biofilms. The impact of these dead bacteria on the survivors is unknown. Preliminary evidence shows that certain surviving pathogenic bacteria can use these remaining dead bacteria as a food source. Thereby, they can have nutritional advantages resulting in an increased growth or pathogenicity. This project aims to investigate the effect of these dead bacteria on the outgrowth and increased virulence of pathogens in dental plaque. By using different models with increasing complexity, clinical reality, a mechanistic model will be demonstrated as close as possible. Finally, a proof of principle will be given in a clinical study. This project might show that care should be given to prevent the indiscriminate use of antiseptic containing toothpastes and mouth rinses, since they might increase the pathogenicity of unremoved dental plaque.
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| Qualifiers | - Dentistry and maxillofacial medicine - |
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| Personal | Teughels Wim |
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